Yields of strand breaks and base lesions induced by soft X-rays in plasmid DNA

Yokoya, Akinari; Fujii, Kentaro; Ushigome, Takeshi; Shikazono, Naoya; Urushibara, Ayumi; Watanabe, Ritsuko

Radiation Protection Dosimetry, 122(1-4), p.86 - 88, 2006/12

https://doi.org/10.1093/rpd/ncl408

We have studied yields of DNA damages induced by soft X-rays obtained from a conventional soft X-ray machine in a LET region between -rays and ultrasoft X-rays. Practically soft X-rays with a broad energy spectrum emitted from a target of heavy metal, such as tungsten, have been widely used not only for radiobiological experiments but also for medical application such as mammography. Radiation weighting factors for these soft X-rays have been assigned to be 1 by ICRP. However, the fraction of a large number of low energy photons in the spectrum (below several tens keV) provided by bremsstrahlung is expected to be more effective for DNA damage induction than -rays since low energy photo- and Auger electrons predominantly ejected in consequence of a photoelectric effect can produce dense clusters of ionization/excitation on DNA molecules. We have examined the yield of DNA strand breaks induced by white soft X-rays (150 kVp, tungsten target). Yields of base lesions revealed by base excision repair enzymes will be also presented.

Time resolved X-ray absorption spectroscopy apparatus using laser plasma as an X-ray source

Yoda, Osamu; Miyashita, Atsumi; *; *; *

Excimer Lasers and Applications III, p.463 - 466, 1991/00

no abstracts in English

Yields of DNA strand breaks and base lesions induced by oxygen K-shell electron ionization

Sugaya, Yuki*; Fujii, Kentaro; Yokoya, Akinari

no journal, ,